5-HT1a receptor antagonists block perforant path-dentate LTP induced in novel, but not familiar, environments
نویسندگان
چکیده
منابع مشابه
5-HT1a receptor antagonists block perforant path-dentate LTP induced in novel, but not familiar, environments.
Numerous studies suggest roles for monoamines in modulating long-term potentiation (LTP). Previously, we reported that both induction and maintenance of perforant path-dentate gyrus LTP is enhanced when induced while animals explore novel environments. Here we investigate the contribution of serotonin and 5-HT1a receptors to the novelty-mediated enhancement of LTP. In freely moving animals, sys...
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The perforant path constitutes the primary projection system relaying information from the neocortex to the hippocampal formation. Long-term synaptic potentiation (LTP) in the perforant path projections to the dentate gyrus is well characterized. However, surprisingly few studies have addressed the mechanisms underlying LTP induction in the direct perforant path projections to the hippocampus. ...
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ژورنال
عنوان ژورنال: Learning & Memory
سال: 2006
ISSN: 1072-0502
DOI: 10.1101/lm.126306